Beilstein J. Org. Chem.2019,15, 79–88, doi:10.3762/bjoc.15.9
conducted. This experiment revealed that the oligonucleotide containing five modified units was able to elicit the RNase H-mediated cleavage of the complementary RNA strand.
Keywords: DNA/RNA affinity; fluorinated cyclopropanes; fluorinatednucleicacids; RNase H activity; sugar modified nucleosides
fluorinatednucleicacids such as 2’-fluorocyclohexenyl nucleic acid (F-CeNA, Figure 1) [27] and other modifications [28][29][30][31] have been analyzed on their antisense properties.
In our own work we already investigated the effect of the fluorine substituent at various positions of the [3.3.0]bicyclo-DNA
PDF
Graphical Abstract
Figure 1:
Chemical structure of selected fluorine-modified nucleic acids.
Beilstein J. Org. Chem.2018,14, 3088–3097, doi:10.3762/bjoc.14.288
modification might be a substrate for RNase H.
Keywords: DNA/RNA affinity; fluorinated cyclopropanes; fluorinatednucleicacids; molecular dynamics simulations; sugar modified nucleosides; Introduction
A powerful strategy for the treatment of various disorders like cancer, viral and inherited diseases is the
PDF
Graphical Abstract
Figure 1:
Chemical structure of selected nucleic acid analogs.